Öz
Giriş
Talasemi Majör hastalarında kalp yetmezliği en önemli ölüm nedenlerinden biri olduğundan, bu hastaların düzenli olarak kalp sorunları açısından kontrol edilmesi gerekmektedir.
Çalışmamızda, Talasemi Majör hastalarında 8 farklı bölgeden alınan nabız dalga doppler görüntüleri ve segmental doku doppler görüntülerinin yanı sıra copeptin, NT-pro ANP, NT-proBNP, CK-MB ve ultra-duyarlı troponin I değerlerinin sağlıklı bireylerle karşılaştırılması planlandı.
Gereç ve Yöntem
Kalp ile ilgili semptomları bulunmayan, 10 yaş üzeri 59 Talasemi Majör hastası iki gruba ayrıldı (Grup 1: T2*<20 msn ve Grup 2: T2*>20 msn). Hasta gruplarının ekokardiyografi verileri ve biyokimyasal parametreleri kontrol grubu ile karşılaştırıldı.
Bulgular
Her iki hasta grubunda NT-proBNP değerleri kontrol grubuna göre anlamlı derecede yüksek bulundu (p<0,001) ve NT-proBNP ile kardiyak MRG arasında ilişki bulunmadı. Mitral anülüsün lateral ve medial kesimlerine ait doku doppler görüntülerinde her iki hasta grubunda da IVCT ve IVRT ölçümlerinin uzadığı ve Miyokardiyal performans indeksi (MPI) ölçümlerinin arttığı görüldü. Grup 1’in E´, A´ ve S ölçümleri kontrol grubuna göre daha düşük bulundu. Copeptin, NT-proANP, CK-MB ve ultra-duyarlı Troponin I değerleri açısından gruplar arasında anlamlı bir fark saptanmadı.
Sonuç
İncelenen biyokimyasal göstergeler demir birikimi ile güçlü bir şekilde ilişkilendirilemedi. Ancak doku doppler ekokardiyografi ile MPI değerleri hesaplanarak, bütünsel kardiyak fonksiyon bozukluğu daha erken tespit edilebilir ve şelasyon tedavisi yeniden düzenlenebilir.
Anahtar Kelimeler:
Talasemi, doku doppler görüntüleme, T2* MRI
Kaynaklar
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